ruin/ 'ruːɪn /

1.noun [u] [of building] 
(destruction) 毁坏

2.noun [of hopes] [ plans etc] 
破灭

3.noun [u] [of person] 
(downfall) 落泊

4.noun [u] 
(bankruptcy) 破产

5.noun [c] 
(old building) 废墟

6.vt.[+clothes] [ carpet etc] 
(spoil) 毁坏

7.vt.[+plans] [ prospects etc] 
葬送

8.vt.[+eyesight] [ health] 
损害

9.vt.[+person] 
(bankrupt) 使破产

10.n pl [of building] [ castle etc] 
ruins 废墟

to be in ruins
 [building,town+] 破败不堪
11.n pl [life] [ plans etc+] 
严重受损